We’re all looking for the next great investment. What does it take to make it big? The Wall Street Journal published it’s “Next Big Thing 2012” list today, ranking the top 50 U.S. companies backed by venture capital. Congratulations to all the companies who made the list, including Venrock portfolio companies Genband (#1), Appia (#22) , Achaogen (#35), Quantenna (#36), Acceleron (#48) and Neoconix (#50). Read more about the underlying investment strategies on the Wall Street Journal.